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When external stimuli excite the vagus nerve, the nerve terminals produce the anti-inflammatory parasympathetic neurotransmitter acetylcholine (ACh), which activates the 7 nicotinic acetylcholine receptors (7nAChR) on monocytes and macrophages

Therefore, hyperbranched MeO-PEG-b-(NIPAAm-co-PBAE) EPR-based NDDSs have the highest tendency to long circulation time and enhanced tumor accumulation 38